The current data showed marginally significantly higher levels of Lp-PLA2 among American compared to Japanese men. There was no significant association between Lp-PLA2 levels with the prevalence of CAC among American men while there appeared to be a negative association between Lp-PLA2 levels with the prevalence of CAC among Japanese men, especially among those with LDL≥130 mg/dL.
With few exceptions (15-17), the majority of clinical and epidemiologic studies among western populations suggested that Lp-PLA2 is an independent predictor of cardiovascular events (CAD and stroke) (9-14). Whether Lp-PLA2 is an independent predictor of CAC or not is less clear. Only two studies examined the association between coronary calcification and Lp-PLA2 levels among white populations with inconsistent findings (18, 19). In a recent report from the Rotterdam Study (19), Lp-PLA2 activity measured concurrently to EBT scanning was not associated with coronary calcification in either men or women. This finding was in contrast to previous findings from the same population that showed Lp-PLA2 as a predictor of CHD and stroke (10). In the Coronary Artery Risk Development in Young Adults (CARDIA) study (18), however, Lp-PLA2 level had a significant and independent association with CAC among young white and black American men and women.
No comments:
Post a Comment