an independent association of Lp-PLA2 mass with
presence of calcified coronary plaque and amount of coronary
calcium and thus supports the notion that Lp-PLA2 may be
relevant to atherogenesis. In this regard, recent evidence indicates that Lp-PLA2 has great affinity for small, dense LDL
particles, known to be more susceptible to oxidative modification and to be atherogenic,33 and that Lp-PLA2 byproducts may
be involved in apoptosis of macrophages and smooth muscle
cells, a process that can lead to atherosclerosis progression
https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000148322.89911.44
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