A study published in the May 2013 Journal of the American College of Cardiology looked at the problem of muscle symptoms and statins in detail.
University of Missouri researchers followed 37 overweight, sedentary participants with two of five risk factors for metabolic syndrome (a condition that increases the risk for diabetes and adverse cardiovascular events).
None of the people in the study had ever taken statins. All began a three-month exercise training program, working up to 45 minutes of treadmill walking or jogging for five days a week. Half received simvastatin, and half did not.
LDL (bad) cholesterol levels fell 40 percent in the statin group and increased slightly in the non-statin group. Yet cardiovascular fitness increased 1.5 percent in the statin group vs. more than 10 percent in the non-statin group. “Muscle biopsies showed that mitochondrial enzyme levels (expected to rise in the cell during exercise) rose 13 percent in the non-statin group but fell 4.5 percent in the statin group despite the increase in exercise,” notes Dr. Sukol.
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