"Blood Cholesterol, Leukocyte Count,
and Recurrence
As expected, total cholesterol and leukocyte count were
major independent and joint predictors of recurrence, along
with the dietary pattern.
A leukocyte count .93109
/L increased
the risk by a factor of 1.6 to 2.9, and each increase of
1 mmol/L of total cholesterol increased the risk of recurrence
by 20% to 30%.
Epidemiological studies have consistently
shown a positive correlation between plasma cholesterol
levels and the incidence of (and mortality from) CHD in
various populations.24,25
Thus, our population does not appear
to be different from other low-risk populations.25,26 In other
words, the data indicate that neither the Mediterranean dietary
pattern nor any major bias has altered the usual and expected
relationships between the major risk factors of CHD and
recurrence."
—The protective effect of the Mediterranean dietary pattern was maintained up to 4 years after the first
infarction, confirming previous intermediate analyses. Major traditional risk factors, such as high blood cholesterol and
blood pressure, were shown to be independent and joint predictors of recurrence, indicating that the Mediterranean
dietary pattern did not alter, at least qualitatively, the usual relationships between major risk factors and recurrence.
Thus, a comprehensive strategy to decrease cardiovascular morbidity and mortality should include primarily a
cardioprotective diet. It should be associated with other (pharmacological?) means aimed at reducing modifiable risk
factors.
Further trials combining the 2 approaches are warranted. (Circulation. 1999;99:779-785.)
Source: Mediterranean Diet, Traditional Risk Factors, and the Rate
of Cardiovascular Complications After
Myocardial Infarction
Final Report of the Lyon Diet Heart Study
Michel de Lorgeril, MD; Patricia Salen, BSc; Jean-Louis Martin, PhD;
Link to the original paper
Furthermore, the
Lyon Heart study showed that adopting
a Mediterranean diet in secondary
prevention improved hard outcomes
for both recurrent myocardial infarction
(NNT=18) and all-cause mortality
(NNT=30), despite there being no significant
difference in plasma low-density
lipoprotein (LDL) cholesterol between
the two groups.
It is the alpha linoleic
acid, polyphenols and omega-3 fatty acids
present in nuts, extra virgin olive oil, vegetables
and oily fish that rapidly attenuate
inflammation and coronary thrombosis.6
Both control diets in these studies were
relatively healthy, which make it highly
likely that even larger benefits would
be observed if the Mediterranean diets
discussed above were compared with a
typical western diet.
Saturated fat does not clog the arteries:
coronary heart disease is a chronic
inflammatory condition, the risk of
which can be effectively reduced from
healthy lifestyle interventions
Aseem Malhotra,1
Rita F Redberg,2,3
Pascal Meier4,5
Link to the original paper
Again there was no difference in cholesterol levels between the two groups which suggests that something else in the diet was having a beneficial effect
Page 72 The Pioppi Diet
Both control diets in these studies were
relatively healthy, which make it highly
likely that even larger benefits would
be observed if the Mediterranean diets
discussed above were compared with a
typical western diet.
Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions
Aseem Malhotra,1 Rita F Redberg,2,3 Pascal Meier4,5
There was a 70% risk reduction in cardiovascular complications by the end of four years, relative to the American Heart Association diet
Page 72 The Pioppi Diet
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