Showing posts with label Magnesium. Show all posts
Showing posts with label Magnesium. Show all posts

Magnesium Oxide

Between 50 to 80 percent of the American population is deficient in magnesium. If you’re one of these people, then chances are you’re taking (or planning to take) a form of magnesium supplement.
Magnesium plays a significant role in human health. In fact, researchers have now detected 3,751 magnesium binding sites on human proteins, according to a report by GreenMedInfo.1 This mineral must be bound to another substance to increase its absorption rate, which is why it’s available various forms.2
When searching for the right type of magnesium supplement to take, one of the most common formulations that you may encounter is magnesium oxide. However, medical studies suggest that this form of magnesium does not really deliver the optimum health benefits that you may expect.3

What Is Magnesium Oxide?

Magnesium oxide is a common type of magnesium supplement that’s widely available in pharmacies all over the country. One of the reasons behind its popularity among supplement manufacturers is its low manufacturing cost.4 Nowadays, magnesium oxide is easily and inexpensively obtained through the calcination of naturally occurring minerals.5
Moreover, the magnesium oxide formula contains around 60 percent elemental magnesium — the highest among all types of this mineral supplement.6 This high percentage may lead people into thinking that this type of magnesium supplement is the best of them all. However, just because it has the highest elemental magnesium does not mean that it’s the best form of magnesium supplement that you should take.
Keep in mind that magnesium oxide is non-chelated, which means that it’s not in a form that’s easily absorbed and metabolized by the body.7 Studies have shown that magnesium oxide only has a 4 percent absorption rate, which is relatively poor compared to that of the other magnesium supplements.8

What Are the Sources of Magnesium Oxide?

Magnesium oxide is obtained by burning magnesium in pure oxygen. However, this process is costly, as metallic magnesium is an expensive material. The cheaper way to produce magnesium oxide is by subjecting naturally occurring minerals, particularly magnesium salts, to a process of thermal treatment called calcination.9
There are two magnesium salts that may be used for this process: magnesium carbonate and magnesium hydroxide.10 The possible sources of these magnesium salts are:11
•Seawater
•Underground brine deposits
•Salt beds
The source of magnesium salt has a great effect on the quality of the calcined material, and this is also the factor that will determine the proper application of the produced magnesium oxide.12 If you’re still considering this supplement, then you should be aware of its other medicinal applications to verify if it’s indeed the right supplement for your needs.

Other Possible Uses of Magnesium Oxide

Aside from increasing magnesium levels, magnesium oxide has also been used to help ease the following conditions:13
•Constipation: The low absorption rate of magnesium oxide gives it a strong laxative property, which can induce bowel movement.
•Acid reflux: Magnesium oxide acts as an antacid that can help alleviate acid reflux.
•Indigestion: Similar to acid reflux, indigestion is also caused by excess acid, which can be neutralized by magnesium oxide.
It’s important to consider magnesium oxide’s laxative property if you’re planning to use it as a supplement because this may cause you to take more trips to the bathroom than usual. If you’re simply taking it to increase the magnesium levels in your body and you’re not really aiming to cure any of the conditions mentioned, then chances are you’ll reach your bowel tolerance long before your body has absorbed a sufficient amount of magnesium.

What’s the Ideal Dosage of Magnesium Oxide?

According to the Food and Nutrition Board, the tolerable upper intake level (UL) for magnesium supplement is 350 milligrams (mg) per day — this dosage is applicable for adults and for children ages 9 years old and above. For kids ages 4 to 8 years old, the recommended UL is 110 mg per day. Moreover, the UL for children between 1 to 3 years old is 65 mg per day.14 However, consult your child’s physician before giving them any type of supplement.
When taking any type of magnesium supplement, make sure that you follow the recommended dose, and don’t make the mistake of increasing the dosage without informing your doctor, as this may lead to adverse side effects.

Side Effects That You May Encounter When Taking Magnesium Oxide

The most common side effects that you may encounter when taking magnesium oxide supplement are abdominal cramping and diarrhea.15 These may be avoided or reduced by eating a meal before taking the supplement. If these symptoms become bothersome, then you should consult your doctor immediately. You should also talk to your doctor if you experience any of these serious side effects:16

Magnesium and strokes



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If you’re looking for a way to decrease your risk of developing coronary heart disease, stroke and type 2 diabetes, new research has revealed profound results from starting a simple new habit: consuming an extra 100 milligrams (mg) of magnesium via your food on a daily basis.
Researchers at Zhejiang University and Zhengzhou University in China found that more than 1 million people across nine countries who consumed the most magnesium tested out with a 10 percent lower risk of coronary heart disease, a 12 percent lower stroke risk and a 26 percent lower risk of type 2 diabetes.
Regarding the new research, which was published in Biomed Central,1 lead study author Fudi Wang, Ph.D., explains:
“Low levels of magnesium in the body have been associated with a range of diseases, but no conclusive evidence has been put forward on the link between dietary magnesium and health risks.
Our meta-analysis provides the most up-to-date evidence supporting a link between the role of magnesium in food and reducing the risk of disease ... Our findings will be important for informing the public and policy makers on dietary guidelines to reduce magnesium deficiency-related health risks.”2
Wang said in a Medical Xpress news release3 that although current guidelines recommend that men take about 300 mg of magnesium a day, and women 270 mg per day, deficiencies in this mineral are still common, affecting anywhere between 1.5 percent to 15 percent of the population.
The researchers hope this new information serves to not just encourage people to make sure they’re getting adequate magnesium, but to prompt policy makers to change dietary guidelines, which could diminish the number of magnesium deficiency-related diseases.

Heart Issues Linked to Low Magnesium, but Science Takes a ‘Wrong Turn’

In 2013, the upshot of a “groundbreaking” review covering what was known about cardiovascular disease from as early as 1937 found that low magnesium levels —not high cholesterol or consumption of too much saturated fat —are the leading cause of many aspects of heart disease.
The 10-year review, conducted by research scientist and author Andrea Rosanoff, Ph.D., was based on the earlier research of Dr. Mildred Seelig, who studied the relationship between magnesium and cardiovascular disease for more than 40 years. Seelig noted:
“These numerous studies have found low magnesium to be associated with all known cardiovascular risk factors, such as cholesterol and high blood pressure, arterial plaque build-up (atherogenesis), hardening of the arteries and the calcification of soft tissues.
This means we have been chasing our tails all of these years going after cholesterol and the high saturated-fat diet, when the true culprit was and still is low magnesium.”4
As early as 1957, Rosanoff says, it was very clear that low magnesium was “strongly, convincingly, a cause of atherogenesis and the calcification of soft tissues. But this research was widely and immediately ignored as cholesterol and the high saturated-fat diet became the culprits to fight.”
The “wrong turn” scientists took when the research was so clear, Rosanoff asserts, created a trajectory in the way heart disease and other cardiovascular issues have been dealt with across the board. This had resulted in entire populations failing to balance their magnesium intake with their calcium intake, and it’s getting worse.
Studies continue to show that when calcium and magnesium intake aren’t on an even keel, Rosanoff asserts, the risk of heart disease increases.

Evidence ‘Much Too Compelling to Ignore’

Medical and naturopathic doctor Carolyn Dean, a member of the Nutritional Magnesium Association’s Medical Advisory Board, asserts that it’s obvious that cholesterol isn’t the cause because statins have been the answer doctors have turned to for their patients for two decades, but heart disease is still the No. 1 killer in America.

Magnesium...not calcium

Calcium is the holy grail of what builds strong bones is  a believe that is absolutely ingrained in our society, but has no basis in reality–calcium is but ONE of the many minerals your body needs for building strong bones.
Dietary intake of magnesium,may be the key to developing healthy bones during childhood, according to new research presented at the Pediatric Academic Societies (PAS) annual meeting in the USA.
Take a Second Peek At Calcium Claims
Age-old myths that calcium supplementation builds strong bones and teeth are reinforced in almost institution. But how effective is calcium supplementation?
A 2004 study showed that people with excess calcium in their coronary artery and who take statins have a 17-fold higher risk of heart attacks than do those with lower arterial calcium levels; researchers concluded that the two most definitive indicators of heart attack were LDL levels and calcium build-up.
A 2007 study showed that calcium from dietary sources has more favorable effects on bone health than calcium from supplements in postmenopausal women (Am J Clin Nutr 2007).
A 2008 study found calcium supplements are associated with a greater number of heart attacks in postmenopausal women (BMJ 2008)
A 2010 meta-analysis showed calcium supplements (without coadministered vitamin D) are associated with increased risk for heart attack (BMJ 2010)
According to the National Osteoporosis Foundation (NOF), food will always be the best source of calcium:
“People who get the recommended amount of calcium from foods do not need to take a calcium supplement. These individuals still may need to take a vitamin D supplement. Getting too much calcium from supplements may increase the risk of kidney stones and other health problems.”
“Calcium supplements have been widely embraced by doctors and the public, on the grounds that they are a natural and therefore safe way of preventing osteoporotic fractures,”
“It is now becoming clear that taking this micronutrient in one or two daily [doses] is not natural, in that it does not reproduce the same metabolic effects as calcium in food,”
On the market you’ll find calcium that can contain calcium carbonate which is a secondary type of calcium and makers put a basic chelating agent like citrus extract to make it more absorbable, however the final item is second rate compared to other calcium supplements like , calcium orotate, which is the main known manifestation of calcium which can adequately enter the layers of cells.
An alternate truth the vast majority are ignorant of is the myth advanced by the dairy business that eating pasteurized dairy items, for example, milk or cheese, builds calcium levels. This is completely false. The purification preparation just makes calcium carbonate, which has truly no chance to get of entering the cells without a chelating agent.
So what the body does is force the calcium from the bones and different tissues keeping in mind the end goal to cushion the calcium carbonate in the blood. This methodology ACTUALLY CAUSES OSTEOPOROSIS. Milk absolutely does not do a body decent in the event that it’s sanitized.
Magnesium and Increasing Awareness
Professor Steven Abrams and his colleagues at the Baylor College of Medicine in Houston found that magnesium intake in children was highly important in healthy bone development.
“Dietary magnesium intake may be an important, relatively unrecognised, factor in bone mineral accretion in children,”
“Lots of nutrients are key for children to have healthy bones. One of these appears to be magnesium.Calcium is important, but, except for those children and adolescents with very low intakes, may not be more important than magnesium.”
The team have said in the near future parents should be advised to monitor their child’s magnesium intake just as much as calcium intake has been highlighted in the past.
Higher magnesium levels are related to higher bone mineral density (BMD) in men and women. There is a 2 percent increase in whole-body BMD for every 100 milligram per day increase in magnesium.
Supplementing With Magnesium
For the dominant part of mankind’s history, the proportion of calcium to magnesium in the eating methodology was 1:1, a degree that is viewed as ideal. A proportion that is somewhere around 1:1 and 2:1 is satisfactory (for instance, 800 mg of calcium to 400 mg of magnesium). Sadly, today’s weight control plans contain a normal of 10 times more calcium than magnesium.
Magnesium  oxide or chloride is fine, as is chelated magnesium and they containers normally contain 250-500 mg of magnesium.
Utilize a calcium/magnesium supplement and  The Recommended Daily Allowance (RDA) for magnesium is 350-400 mg every day, in spite of the fact that for ideal levels, you may require as much as twice that sum.
Take your magnesium in isolated measurements for the duration of the day. You can take it either on an empty stomach or with meals.
Also  add Epsom salts to your baths–Epsom salt is magnesium sulfate. It’s absorbed through the skin and will help replenish magnesium stores. This “treatment” can easily include a relaxing bath with a good book.
One percent of the body’s magnesium is in the blood, and the body will take it from bones and tissues if that level drops. That means that a blood test could easily show a normal reading, even when the rest of the body is very deficient.
The best sources of magnesium is  food so eat more green leafy vegetables,cacao, seeds, and nuts of any kind are among the highest food sources in magnesium.

Science denies your pain

In my Apr. 23, 2016 blog I wrote about Statins & Muscle Pain and described how the drug industry tries to cover up the muscle pain side effects of statins. In June 2017 The Lancet published “Statin-associated muscle symptoms: beware of the nocebo effect.” This is a study that actually denies that statins have side effects and “scientifically proves” that it’s all in the patient’s head! They reference the Nocebo effect, which is the opposite of the Placebo affect. It’s the most condescending attitude toward patients that I’ve witnessed in recent years.
The article was funded by a manufacturer of atorvastatin and reanalyzed data from a previous study (Lancet 2003; 361:1149). The preamble to the article admits that “patient-reported statin intolerance, predominantly due to statin-associated muscle symptoms (SMS) is a common and difficult-to-manage condition affecting millions of patients worldwide.” It is reported in about one fifth of patients. We don’t know how many patients just put up with the side effects and don’t complain. The researchers hired by the makers of the statin drugs say that “the development of SMS does not necessarily signify statin intolerance since statin therapy might not always be pharmacologically involved.”
Drug trials are strange beasts in or of themselves. What about the Hawthorne Effect (AKA the observer effect) in which individuals modify an aspect of their behavior in response to their awareness of being observed. We take that effect and divide humans into two camps – those who like to complain and those who don’t. Couldn’t the Hawthorne Effect explain the results of this study? To me this effect, and the fact that studies are manipulated to get the results that drug companies want, make them almost useless.
Another Lancet study, Mar. 18, 2017 called Safety and Efficacy of Statins describes how the actual occurrence of muscle pain in patients on statins is derived. They subtract the number of patients who report pain on the placebo from patients who report pain on the statins! Does that make any sense at all?
Add to this murky soup a paper in Expert Rev Clin Pharmacol March 2015 called “How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease.”
Here is the abstract of this 2015 paper:
We have provided a critical assessment of research on the reduction of cholesterol levels by statin treatment to reduce cardiovascular disease. Our opinion is that although statins are effective at reducing cholesterol levels, they have failed to substantially improve cardiovascular outcomes. We have described the deceptive approach statin advocates have deployed to create the appearance that cholesterol reduction results in an impressive reduction in cardiovascular disease outcomes through their use of a statistical tool called relative risk reduction (RRR), a method which amplifies the trivial beneficial effects of statins. We have also described how the directors of the clinical trials have succeeded in minimizing the significance of the numerous adverse effects of statin treatment.
In spite of the facts in the above abstract, the pro-statin camp thinks statins are so wonderful that we should just put them in our drinking water and not tell anyone about the potential dangers because then people will just imagine they are having side effects! For the anti-statin view, I tell people to read an insightful and witty critique of the statin industry in Dr. Malcolm Kendrick’s book, The Great Cholesterol Con.
In my blog Cholesterol is Not Your Enemy I remind readers that doctors “want to blame heart disease on something and cholesterol does seem convenient.” To try and convince patients that cholesterol is bad, when it’s not, is one thing. But when they are forced to take a drug that has side effects and they are told that any side effects are all in their heads, that’s Draconian.
What do I recommend? Magnesium of course. For years I’ve talked about one of the functions of magnesium – its ability to lower cholesterol. Here is an edited abstract from the J.Am.Coll.Nutr. 2004 Oct;23(5):501S-505S, by Rosanoff and Seelig:
Mg(2+)-ATP is the controlling factor for the rate-limiting enzyme in cholesterol biosynthesis. Formation of cholesterol in blood, as well as of cholesterol required in hormone synthesis, and membrane maintenance, is achieved in a series of enzymatic reactions that convert HMG-CoA to cholesterol. The enzyme that deactivates HMG-CoA Reductase requires Mg, making Mg a Reductase controller rather than inhibitor. Mg is also necessary for the activity of lecithin cholesterol acyl transferase (LCAT), which lowers LDL-C and triglyceride levels and raises HDL-C levels. Desaturase is another Mg-dependent enzyme involved in lipid metabolism. Desaturase catalyzes the first step in conversion of essential fatty acids (omega-3 linoleic acid and omega-6 linolenic acid) into prostaglandins, important in cardiovascular and overall health.
Carolyn Dean MD ND

Magnesium deficiency

A lack of  magnesium will impede your cellular metabolic function and deteriorate mitochondrial function, which in turn can lead to more serious health problems. Eating plenty of organic unprocessed foods tend to be your best bet, but since most soils have become severely depleted of nutrients, some magnesium experts believe virtually everyone needs to take supplemental magnesium. As noted in a 2001 paper on the pathology of magnesium deficiency:13
“Unfortunately, [magnesium] Mg absorption and elimination depend on a very large number of variables, at least one of which often goes awry, leading to a Mg deficiency that can present with many signs and symptoms. Mg absorption requires plenty of Mg in the diet, [selenium] Se, parathyroid hormone (PTH) and vitamins B6 and D. Furthermore, it is hindered by excess fat.
On the other hand, Mg levels are decreased by excess ethanol, salt, phosphoric acid (sodas) and coffee intake, by profuse sweating, by intense, prolonged stress, by excessive menstruation and vaginal flux, by diuretics and other drugs and by certain parasites (pinworms). The very small probability that all the variables affecting Mg levels will behave favorably, results in a high probability of a gradually intensifying Mg deficiency.”

Ailments Associated With Magnesium Deficiency

Magnesium deficiency

Some common signs of magnesium deficiency include:

  • Unexplained fatigue or weakness
  • Abnormal heart rhythms, heart ‘flutters’ or palpitations
  • Muscle soreness or spasms
  • Eye twitches
  • Anxiety, depression or restlessness
  • Inability to sleep or insomnia
  • Infertility or PMS
  • Headaches
  • Fuzzy brain or difficulty concentrating
  • Thyroid problems
  • Testosterone deficiency or low testosterone levels


  • Unfortunately a significant portion of the population are deficient in magnesium. In fact, it is estimated that over 50% of people have insufficient stores of magnesium.
    Moreover, there are a range of medications that can deplete magnesium from the body, resulting in magnesium deficiency, and ultimately, a low testosterone level.
    If you are taking any of the medications listed below, then your risk of magnesium deficiency increases dramatically.
    This is because these drugs either reduce the absorption of magnesium from our diet or deplete tissue stores.

    The 10 Medications That Cause Magnesium Deficiency:

  • Acid blockers (proton pump inhibitors) and antacids
  • Antibiotics
  • Antiviral agents
  • Blood pressure drugs
  • Diuretics
  • ADHD drugs/ stimulants
  • Anticonvulsants
  • Corticosteroids
  • Testosterone replacement therapy (TRT)
  • Oral contraceptives
  • Other foods and beverages that can lower magnesium stores include alcohol, coffee, nicotine, and high-sugar diets.

    Magnesium supplements

    Modern diets have been robbed of sufficient magnesium levels through use of over-processed foods, and lack of available soil nutrients. Parasites, candida, and many other micro-flora within the body are all consumers of magnesium, and can often take a large percentage of overall intake. That means that for every milligram of magnesium you consume, your body has to fight against competitors to be able to use it. Those with worrisome amounts of bacteria and fungus in their bodies can often lose these battles, leaving their body with less magnesium than it needs to function properly.
    Magnesium supplements offer a powerful means to rein in control of this battle, balancing the odds in your favor. Specialized forms of magnesium are able to be better absorbed than others, and are better suited for different situations. Most magnesium supplements are blends of several different forms, and often contain other minerals such as calcium or potassium. The most basic types of magnesium supplements are generally Magnesium glycinate, magnesium malate, magnesium taurate, magnesium threonate, and magnesium citrate. There are certainly more types of this mineral available, but these are the most commonly seen in supplements. Gaining a better understanding of what magnesium is, and how it functions in your body, will help you better understand which magnesium supplement will be the best for your personal goals and circumstance.

    What is Magnesium

    Magnesium is an elemental compound found naturally in many different foods, supplements, and natural formations of the Earth. This vital mineral is responsible for the regulation and proper execution of over 300 enzyme processes in your body. It regulates protein synthesis, regulates blood pressure, and ensures healthy nerve function. Magnesium is responsible for helping bone to form, in DNA and RNA synthesis and repair, contributes to the production of antioxidants within your body, and even helps your body use other minerals like calcium and magnesium.4 When  so many aspects of your body are entwined with the availability of magnesium, it’s easier to understand the horrible effects a magnesium deficiency can have on your body. Magnesium is without doubt, one of the most important minerals for your body to be able to function in a healthy capacity.
    Magnesium is responsible for the regulation and proper execution of over 300 enzyme processes in your body, regulates protein synthesis, regulates blood pressure, and ensures healthy nerve function.
    The average person has 25 grams of magnesium in their body at any given time. Most of this amount is found within bones and soft tissues such as cartilage, leaving a measly 1% left in the blood 4. This 1% is the magnesium that is available to your body to use in the wide array of cellular and enzymatic processes needed to function properly. Even a slight drop in this level, called your serum magnesium level, can cause a disruption in your body’s most fundamental processes—leading to a cascade of health issues if not addressed quickly and effectively 6. The Recommended Daily Allowance (RDA) for magnesium is 400mg daily for men, and 310mg for women 4. These figures represent the bare minimum amount of magnesium your body needs to function properly. Eating foods high in magnesium, and using supplements if you are have health issues such as parasites or candida is a great way to help ensure you never fall below this threshold.

    Optimal Magnesium Levels

    Health professionals are constantly learning more processes of body which are dependent on magnesium for proper function, and also many more major diseases and chronic illnesses in which magnesium deficiencies place a very affective role 8. For this reason, it is critical that you make sure you are receiving at least the RDA of magnesium, and in most cases should consider adding a magnesium supplement to your diet to ensure proper bio-availability. Magnesium is considered a very safe compound, with magnesium supplements having only a few very mild side effects. The signs of a magnesium overdose include excessive urination, diarrhea, and fatigue 9 . The chances of accidental magnesium overdose are extremely small— and are usually only seen when testing for your personal bowel tolerance of magnesium. There is no practical way that you would ever have an overdose of magnesium from eating too many high magnesium foods. The only real way to experience a magnesium overdose is to purposefully take an excessive amount of magnesium supplements. In some cases of kidney dysfunction, magnesium overdoses can present—but in these cases much larger issues are likely at hand.
    There is no practical way that you would ever have an overdose of magnesium from eating too many high magnesium foods
    Purposeful magnesium overdoses are clinically used to help induce bowel movements in patients suffering from constipation or preparing for a colonoscopy. One of the best ways to understand how much magnesium is right for you, is to perform what doctors call a magnesium bowel tolerance test. This is typically done using a magnesium citrate supplement, and is conducted over the course of several days. One of the main side effects of a magnesium overdose is diarrhea. A magnesium bowel tolerance test is basically just a process of upping your dose of magnesium over several days until you get diarrhea. A typical approach for this would be to take have a magnesium supplement offering around 150mg per capsule. The first day, you’d take one with each meal. The second day you’d take two capsules (a total of 300mg) with each meal. You would continue this process until your stool becomes loose, or you have diarrhea. This is your bowel tolerance level, which can be used for better understanding your magnesium needs as an individual. The higher your bowel tolerance level, the higher your likelihood for magnesium deficiencies or bio-availability issues brought on by parasite type infections.

    Bioavailability of Magnesium

    As mentioned earlier, magnesium is found in many different forms. Different magnesium supplements offer different forms of this mineral, and each is suited for different circumstances. These different types of magnesium supplements are able to help address many different types of individual needs. If you have few high magnesium foods in your diet, you’d likely be best served with a magnesium citrate supplement. If you suffer from conditions such as SIBO or parasites, you would likely benefit the most from a magnesium glycinate supplement. If you’re interest in magnesium supplements is more focused on the neurological benefits, magnesium threonate would likely be the best magnesium supplement for you. Each of these forms of magnesium are used by your body in different ways, and to understand which one may be the best magnesium supplement for you, it’s advised to learn more about the benefits of each.
    Magnesium found in many plants is often locked away tightly inside the cell structures of the plant, and requires complex enzymatic processes to make it available for your body to use
    One important factor in finding the best magnesium supplement for you is to be mindful of the bioavailability of each. Bioavailability is a pseudo-scientific term which describes your body’s ability to utilize it. This attribute is best illustrated through the magnesium found in foods. Many foods are high in magnesium, but your digestive system has to first ‘unlock’ it. The magnesium found in many plants is often locked away tightly inside the cell structures of the plant, and requires complex enzymatic processes to make it available for your body to use.10 Magnesium supplements on the other hand, come in already isolated forms. For example, if you ate an amount of spinach you knew to contain 1 gram of magnesium, your body wouldn’t likely have access to that full amount. However, if you take 1 gram of magnesium in supplement form, your body would have instant access to that amount. This issue of bioavailability is still just the first hurdle in ensuring optimal magnesium levels, and just because it is available to your body doesn’t mean it gets used as it should.

    Different Types of Magnesium Supplements

    As with many compounds in the body, magnesium’s ability to be utilized by the body is co-dependent on several other compounds—most notably calcium, vitamin D, and vitamin K2. These minerals are naturally found together in many foods, which is why it is recommended to try and achieve optimal magnesium levels through diet before moving on to supplements. When you start introducing supplements into your diet, you run the risk of shifting your overall balance drastically, which could lead to unforeseen side effects. Many known and unknown conditions can lead to your body’s inability to properly access optimal levels of magnesium through diet alone. In cases such as these—or if you simply want to be sure you get enough magnesium—magnesium supplements offer a powerful benefit in achieving optimal levels of magnesium. Different types of magnesium supplements offer different benefits, and are optimized for different circumstances. Below, you’ll find a brief overview of the most common types of magnesium, and which situations they are best suited for.

    Magnesium Glycinate

    Metagenics Magnesium Glycinate
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    Magnesium Glycinate is the magnesium salt of a compound called glycine—which is an amino acid. Common variations of of this form are magnesium diglycinate and magnesium bisglycinate. These forms of magnesium are commonly found in ‘chelated’ magnesium products, and are the all-around most easily absorbale for your body. Magnesium Glycinate is often recommended by health professionals to patients that are seeking to raise magnesium serum levels for treatment of Hypomagnesemia—the clinical term for magnesium deficiency. Magnesium Glycinate is much less dependent on the acidity levels of the stomach, and is thought to be absorbed by the body through channels utilized by amino acid absorption. If you are suffering from a known magnesium deficiency, magnesium glycinate is usually the best option to help correct that quickly, since it has a fairly high bowel tolerance level. If you’re looking for a type of magnesium that doesn’t cause diarrhea, this is likely your best option for oral use.

    Magnesium Oxide

    Magnesium Oxide
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    Magnesium oxide is a less bioavailable form of magnesium that is typically used to treat acid reflux and sour stomachs. The low bioavailability of magnesium oxide makes it an ideal candidate for those seeking to alleviate constipation. This form of magnesium is commonly referred to as milk of magnesia, and has been a common home remedy to centuries. Milk of magnesia is a white liquid form of magnesium that has a very chalky consistency. This remedy is taken as an oral solution for treating heart burn, indigestion, and stomach aches. When magnesium oxide reacts with water, it becomes magnesium hydroxide. Strictly speaking, milk of magnesia supplements and solutions are really magnesium hydroxide—but that really just means that magnesium oxide has been mixed with water. This type of magnesium supplement isn’t recommended for those with magnesium deficiencies. You would likely hit your bowel tolerance long before you were able to add enough absorbable magnesium with this supplement.

    Magnesium Citrate

    Magnesium Citrate
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    Magnesium citrate is a combined form of magnesium and citric acid. Unlike most other types of magnesium supplements, magnesium citrate has an acidic pH, and is often used as a food additive to regulate overall acidity. Magnesium citrate is only ~13% magnesium by weight—the rest being citric acid. When taken, this form of magnesium has the ability to attract water inside your body, pulling it towards your colon through a process know as osmosis.  This use of magnesium citrate is often utilized by doctors preparing patients for a colonoscopy—since over hydration of the color will lead to bowel evacuation. For those on non-oxalate diets, or low-oxalate diets, citrates such as calcium and magnesium citrate have been shown to bond to oxalic acid molecules 11, thus helping the body to properly eliminate oxalates. Magnesium citrate is a good form of magnesium if you are simply looking to help maintain healthy serum magnesium levels. It offers your body access to an increased amount of magnesium, while at the same time helps to regulate healthy bowel cycles.

    Magnesium Malate

    Magnesium Malate
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    Magnesium Malate is a type of magnesium supplement that is found paired with malic acid. Malic acid is commonly found in fruits, and is regarded by many as being ideal for targeted fatigue-specific conditions. Magnesium Malate has been used in several studies investigating the ability of magnesium to treat conditions such as depression, diabetes, and cardiovascular disease. One study, conducted with mice 12, did find a significant impact on blood-glucose levels, amylase activity, and overall calcium/magnesium ratios in blood serum levels. Malic acid is known to be integrally involved in your body’s Krebs Cycle, which is where much of your cellular energy is generated. With this in mind, it’s very conceivable how Magnesium malate supplements would be effective in helping to address issues such as chronic fatigue syndrome or depression. Magnesium malate has become a much more popular form of magnesium in recent years, and high quality magnesium malate supplements available on the consumer market.

    Magnesium Taurate

    Magnesium Taurate
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    Magnesium taurate is a form of elemental magnesium that has been combine with an amino acid called Taurine. Taurine is thought to be one of the most beneficial elements in helping to promote longer lifespans. Research has shown that Taurine in itself has been able to reduce the risk of heart attacks by up to 80%, balance electrolyte levels, and promote healthy immune function.13 Additionally, magnesium taurate supplements have demonstrated the ability to treat cases of depression 14, vascular health, and the prevention of neurodegenerative disorders and migraines.15 in clinical settings. Magnesium Taurate can be slightly more difficult to find than other forms of magnesium, but with the rising demand among health-conscious buyers—it is becoming more available. L-Taurine is also considered to be a powerful nootropic compound, capable of improving overall cognitive function and memory. This close association of magnesium taruate and taurine lead many to believe magnesium taurate to be one of the better suited magnesium supplements for brain health.

    Magnesium Threonate

    Neuromag Magnesium Threonate
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    Magnesium Threonate is a relatively new form of magnesium that has been shown to be very effective in the treatment of neurodegenerative conditions such as Alzheimer’s disease 16. This form of Magnesium was developed at MIT with the specific intention of finding a form of magnesium that could be more readily-absorbed by the brain 17. It’s marketed as being a nootropic, capable of enhancing cognitive functions such as short-term memory, as well as overall alertness. Magnesium Threonate is the only compound discussed in this article that is considered to be a synthetic—meaning someone holds a patent restricting the ability of other companies to manufacture it. For this reason, Magnesium Threonate is often seen to be more expensive than other forms of the the mineral. The only readily-available research on this compound is either directly, or indirectly (via author) to Magceutics—the company that owns the patent. The most cited study, Genetic enhancement of learning and memory in mice, lists Guosong Liu as an author, whom is also the owner of Magceutics.

    Magnesium Supplement Side Effects

    Magnesium supplements pose very little risk of side effects in most all cases. Some people that suffer from poorly functioning kidneys may have some difficulty in eliminating excess amounts of magnesium. People suffering from such renal conditions as this are likely very aware of their condition and under frequent advisement and monitoring by a licensed professional. In people with normal functioning kidneys, any excess magnesium is passed out of the body through urination. Large doses of magnesium are used clinically to induce colon evacuation, and are known to cause diarrhea. This is a natural response by your body, and shouldn’t be regarded with much concern unless the diarrhea persists after reducing your magnesium intake. Excess amounts of magnesium are also known to cause fatigue—often reported as an ‘over-relaxed’ state rather than just simply being tire.
    Magnesium supplements post very little risk of side effects in most all cases
    Magnesium is also know to have undesirable interactions with certain drugs, such as antibiotics, ant-acids, insulin, diuretics, and some hormonal replacement therapies 18. It is recommended that you consult your doctor if you are on any of these medications and plan on starting a magnesium supplement. Many prescription medications that have been reported to be in conflict with magnesium supplements have been shown to be less absorbable without magnesium. This hints that the dangers might not necessarily be in any alteration of the efficacy of the drugs, simply in their potency. In many cases, the medications that are less absorbed while taken with magnesium are commonly-prescribed for conditions that magnesium has been shown to be effective in treating anyway. Curiously, most of the research outlining potential interactions doesn’t clearly state whether the intended outcome of treatment—the patient getting better—was still achieved.

    Best Magnesium Supplements

    Overall, all forms of magnesium available on the consumer market ultimately provide the proven benefits of magnesium in the treatment of many major diseases such as depression, heart-attacks, diabetes 6. That being said, this list represents an ‘all things considered’ type of metric, and lists those magnesium supplements that are of high quality, high bioavailability, and are most easily administered. Your individual needs should largely influence your decision on which magnesium supplement stands to best meet your goals. Magnesium has only few mild side effects—it’s generally regarded as safe to experiment with different types to better understand which ones are best for you. Below, is a list of some of the best options for each of the types of magnesium discussed in this article. These supplements are all made from manufacturers that take quality and purity of ingredients very seriously. These supplements are all produced in cGMP certified facilities, have each batch checked for toxins and heavy metals, and are all certified to be free of allergens such as wheat, gluten, and dairy.