The role of Vitamin B in stroke prevention

The role of vitamins in stroke prevention has been studied for decades. Folate and cyanocobalamin (vitamin B12) are important regulators of the metabolism of homocysteine. Studies have shown that low levels of these factors are associated with elevation of homocysteine in the blood.1,2 

Hyperhomocysteinemia has been associated with premature atherosclerosis with an increased risk of cardiovascular events.3,–,5 

On the basis of epidemiological studies, clinicians and scientists expected that homocysteine-lowering therapy (HLT) with appropriate doses of folic acid, Vitamin B6, and Vitamin B12 supplementation would reduce the incident risk of cardiovascular diseases (including stroke)

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